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This study further provides new theoretical evidence for the treatment of DKD

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One of the most interesting features of one carbon metabolism is that reaction velocities are often affected not just by substrate and product concentrations and enzyme activities but also by the concentrations of substrates in distant parts of the reaction network that act as allosteric activators or inhibitors of the enzyme

Frijhoff J, Winyard PG, Zarkovic N, Davies SS, Stocker R et al (2015) Clinical relevance of biomarkers of oxidative stress