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While direct evidence linking the RARA::RXRA and RARA::RXRG complexes to CCL11 expression in the CNS is currently not well established, it is plausible to speculate that retinoic acid signaling through these complexes could inhibit CCL11 expression in specific brain conditions

SALL4 deletions are a common cause of Okihiro and acro-renal-ocular syndromes and confirm haploinsufficiency as the pathogenic mechanism

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