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The results highlight the considerable capability of the DNZ-NLPs to traverse the BBB, a feature that is critical for the development of therapeutic strategies aimed at neurodegenerative disorders such as HD, offering promising implications for the treatment of central nervous system diseases

GI dysfunction, a common comorbidity in PD, further contributes to fluctuations in levodopa absorption and plasma concentrations, thereby triggering or exacerbating the on-off phenomenon [86, 87]

The ideal candidate is a patient who has hit a hard plateau on a GLP-1 receptor agonist and complains of significant fatigue or lethargy

Rare side effects may include temporary numbness at administration site, mild headache, or dizziness