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In response to extrinsic stimuli, inositol 1,4,5-trisphosphate (IP 3 ) and ryanodine receptors release Ca 2+ from the ER to the cytosol, whereas the sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) pumps Ca 2+ against the gradient to maintain a concentration difference between the ER lumen and the cytosol at rest

In addition, the expression of SLC2539 was not associated with the clinical characteristic in our cohort (n=49, Supplementary Table S4)

Kidney and cardiovascular outcomes SURPASS-4 kidney composite HR 0.58, slower eGFR decline (-1.4 vs -3.6 mL/min/1.73m2/yr), UACR -6.8% vs +36.9%

Characterization of the oxidase activity in mammalian catalase