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Patients with hyperoxaluria are at a higher risk of vascular dysfunction, including hypertension and atherosclerosis

81 GPX1 decient mice develop normally but are more susceptible to lung inammation by inuenza infection or cigarette smoke exposure

Similarly, compounds from the spiro-oxindole dihydroquinazolinone series identified in the screening, e.g., 42 are weak inhibitors and besides that not stable in in vitro assays