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Cagrilintide, a long-acting human amylin analogue, exerts both central and peripheral effects by enhancing satiety, delaying gastric emptying, and modulating postprandial glucagon secretion, whereas semaglutide acts on GLP-1 receptors in the central nervous system and peripheral tissues to regulate appetite, glycemic control, and energy balance

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2006), while deeper or smoother variants impose stronger inequalities by preserving at least one optimal dual solution or by allowing controlled coverage exchanges (Gschwind and Irnich 2016, Haghani et al