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10.3390/ijms21072464 36 ChoiJ

In many women, these metabolites get out of balance because of an issue with Phase 1, 2, or 3 of the process

Patients can elect to use topical anesthetic cream if they desire, although this is normally not required

This concern appears to stem from glutathione's skin-brightening mechanism, which works by inhibiting melanin production through tyrosinase modulation a temporary, dose-dependent, and generally reversible effect, not an autoimmune depigmentation process like vitiligo