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This snowball effect overwhelms the detoxification pathways, causing more oxidative stress, which leads to immune system activation and sometimes allergies

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In conditions of nutrient depletion, ULK1 is activated, which leads to phosphorylation of the components of the Class III PI3K vacuolar protein sorting 34 (VPS34) protein complex, resulting in the formation of autophagosome and promoting the autophagy flux [255]