Hesperidin can regulate lipid metabolism (upregulating PPAR, CPT1, ACOX1, and ACADM, downregulating HADH, SREBP-1C, and SCD1) and the gut microbiota (mainly increasing the Bacteroidetes / Firmicutes ratio), participating in the regulation of lipid metabolism ( Firmicutes / Bacteroidetes ratio and the abundance of Bacteroidetes and Lactobacillus ) ( In summary, the research found that botanical drugs and their active metabolites can participate in regulating the gut microbiota and SCFAs levels, improving bile acid metabolism, modulating related hormones of the BGA, and regulating inflammatory factors
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Lyophilised Dihexa stored at 20C maintains structural integrity for 1224 months, but once reconstituted with bacteriostatic water, the solution must be refrigerated at 28C and used within 28 days
