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Trials of combination NRT were used to inform this estimate because: (1) randomized trials of a high-dose nicotine patch are not available to inform the projected treatment size, and (2) similar to nicotine patch, combination NRT also allows upward titration to reach satiety

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Thus, the exposure doses used and the missing of important information in the paper prevent the drawing of firm conclusions from the experiment

Pro Tip: Start with a variety pack or sample sizes to test different strengths and flavors before committing to larger quantities