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On the other hand, the most targeted strategy involves hypoxia-activated prodrugs (HAPs) [490, 491] designed for the hypoxia-ROS microenvironment

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These observations are corroborated at the molecular level, with dysregulation in the expression of pro-proliferative proteins (e.g., cyclin D1) and tight junction proteins (e.g., zonula occludens-1, occludin, and claudin 1, 4, and 8) (Birder, 2019)