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10.1104/pp.110.153957 12 ChenJ

This triggers the release of critical apoptogenic factors including cytochrome C (Cyt C), second mitochondria-derived activator of caspases/direct inhibitor-of-apoptosis protein (IAP)-binding protein with low pI (Smac/Diablo), Omi serine protease (HtrA2), apoptosis-inducing factor (AIF), and endonuclease G (ENDOG) [78,79,80,81,82,83]

l-carnitine and creatine treatments demonstrate improved muscle endurance for specific LMNA mutants (L35P and R453W), offering potential therapeutic options for muscular laminopathy

it is a relative potency ratio , not a measurement of benefit and not anything measured in a human