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Turner syndrome (monosomy X) is observed in 45% of POI cases, manifesting with accelerated follicular atresia due to haploinsufficiency of X-linked genes such as BMP15 [94]

Murthy SB, Patnana SV, Xiao L, Rohren E, Hofstetter WL, Swisher SG , Liao Z, Lee JH, Bhutani MS, Macapinlac HA, Wang X, Ajani JA

Additionally, RSV is a known activator of sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase involved in cellular stress resistance, metabolic regulation, and longevity

Future outlook: what comes next for both compounds The peptide weight loss landscape is evolving rapidly, and both cagrilintide and retatrutide sit at the center of that evolution