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Several variants were common, including AX-13163261 (46.9% heterozygous, 19.9% homozygous) (Figure 3A, B)

Studies have shown that NF-B and MAPKs (three major kinases: JNK, p38 and ERK) are expressed in cultured RA-FLSs and easily activated by IL-1 and TNF- (210)

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