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The transient elevation of peripheral cytokines, such as IL-6 induces sustained effects through the following mechanisms: 1) Activated microglia can sustain a pro-inflammatory phenotype over extended periods, thereby potentially becoming a continuous source of IL-1 and TNF- within the central nervous system (127, 128)

A 2008 paper in the Journal of Pharmacological Sciences , for example, carries the PL14736 / Pliva designation in its title while describing fistula-healing experiments in rats, and situates the peptide explicitly within that trial program [4]

Limitations: Heart disease is multifactorial

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