Interestingly, a recent study showed that despite the low plasma concentration of polyphenols, polyphenols were transported to the arterial intima at pH 7.4 in the form of bound lipoproteins, and polyphenol levels were significantly elevated in endothelial cells and macrophages (148)
Tang M, Abbas HA, Negrao MV, Ramineni M, Hu X, Hubert SM, Fujimoto J, Reuben A, Varghese S, Zhang J, Li J, Chow CW, Mao X, Song X, Lee WC, Wu J, Little L, Gumbs C, Behrens C, Moran C, Weissferdt A, Lee JJ, Sepesi B, Swisher S, Cheng C, Kurie J, Gibbons D, Heymach JV, Wistuba II, Futreal PA, Kalhor N, Zhang J
Glutathione is an antioxidant tripeptide that is made up of three amino acids: cysteine, glycine, and glutamate
In 2021, plasma samples from the validation cohort were collected from 102 sibling pairs (102 unaffected and 102 konzo affected, 98 sex-matched, 4 pairs who are discordant for sex) in the Kahemba region of the Democratic Republic of the Congo
