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In general, A plaques in the striatum are linked to lower levels of motivation and dopamine transporter (DAT) expression ( Anxiety-like behavior and related pathology in AD mouse models Anxiety-like behaviors can be assessed using various behavioral tests, including the open field test (OFT), elevated plus maze (EPM), light-dark box, social interaction, and novelty-suppressed feeding

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However, inflammatory cytokines can reach the brain, via the blood circulation, vagus nerve and lymphatic system, from the peripheral immune system [89,90]