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Side Effects: Sedation Parkinsonism symptoms QT prolongation (may be significant if taking with drugs inhibiting CYP3A4/5 or 2D6) Pharmacokinetics: undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 deuterated active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug twice a day dosing effect half life 9.4 hours (Schneider et al, 2021) HT: Resistant Hypertension

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It was an excellent performer in our testing, dropping smoke levels by 99% and 96% on its highest and midlevel (the fourth of seven) fan speeds, respectively

In the case of newer low-nitrosamine smokeless products, research suggests that the risk is no more than 10 percent that of cigarette smoking, and possibly much less