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J Biol Chem 288(35):2508825097

Key Takeaways Standard cagrilintide dose : The maintenance dose is 2.4 mg administered subcutaneously once weekly , established through Phase 3 clinical trials Dose escalation matters : Gradual titration over 16-20 weeks minimizes gastrointestinal side effects and improves tolerability Combination therapy shows superior results : CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) demonstrated 22.7% mean weight loss at 68 weeks Dose-dependent effects observed : Phase 2 trials tested doses from 0.3 mg to 4.5 mg, with 2.4 mg offering optimal balance of efficacy and safety Proper administration technique : Injection sites include abdomen, thigh, or upper arm with rotation recommended to prevent lipodystrophy What Is Cagrilintide and How Does It Work

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