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Nat Rev Mol Cell Biol 17:564580

The role of interleukins in colorectal cancer

CJC-1295 Backbone Clinical Data Relevant to the No-DAC Research Profile Two randomised, placebo-controlled, double-blind, ascending-dose clinical trials of CJC-1295 DAC which shares the same tetrasubstituted GHRH backbone as the no-DAC variant produced dose-dependent increases in mean plasma GH concentrations of 2 to 10-fold for 6 days or more, and mean IGF-1 concentrations of 1.5 to 3-fold for 911 days