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In summary, simultaneously targeting neuroinflammation and ferroptosis pathways is a feasible strategy, offering new hope for patients with treatment-resistant depression

21 In mice, pre-treatment with n-acetylcysteine prevents toxicity from even a very high acetaminophen dose

NAD + can inhibit the release of presynaptic glutamate, reduce the induced excitatory postsynaptic current, and weaken excitatory neurotransmission, thereby inhibiting bilirubin-induced hyperexcitability of ventral cochlear nucleus neurons [124]