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Human clinical trials are scarce, and long-term safety, optimal dosing, and potential side effects remain unclear

Mayo Clinic - Vitamin B12 deficiency anemia National Institutes of Health (NIH) - Vitamin B12 Fact Sheet for Health Professionals Harvard Health Publishing - Vitamin B12 deficiency: What to know NHS (National Health Service) - Vitamin B12 or folate deficiency anemia American Academy of Family Physicians - Diagnosis and Treatment of Vitamin B12 Deficiency

In research models where precise mechanistic attribution matters, simultaneous full-dose introduction is methodologically weak

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