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Who really benefits B12 shots make the biggest difference for people who are genuinely low, including: People with a diagnosed B12 deficiency Vegans and vegetarians, since B12 comes mainly from animal foods Older adults, who absorb B12 less efficiently People with pernicious anemia or digestive conditions that block absorption How to use B12 shots the right way If you decide B12 shots fit your plan, treat them as one piece of a bigger picture: Build the plan on food