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Where acetylation at lysine 305 was found to inhibit the enzymatic activity of PKM2 and promote its degradation through molecular chaperone-mediated autophagy (51), acetylation of PKM2 at lysine 433 promotes the translocation of PKM2 from the cytoplasm to the nucleus and promotes protein kinase activity (52)

10.2174/2215083808666220513143957 59 PitknenA.SutulaT

Archived (PDF) from the original on 18 May 2016

Reactive oxygen species (ROS), together with reactive nitrogen species (RNS), represent the most important prooxidants whose excessive accumulation leads to oxidative stress (OxS) and molecular damage ( ROS are crucial in thyroid function because they are essential in the initial stages of thyroid hormone synthesis during iodide oxidation ( Aerobic organisms have evolved multiple antioxidant and repair systems for protection against OxS