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Another source of evidence comes from a 2020 retrospective study of 98 EDS patients which reviewed various treatments for pain management

Within each active month, the 5-days-on, 2-days-off schedule follows the same logic at the weekly level: it prevents tachyphylaxis (diminished response from constant exposure) while maintaining enough stimulus frequency to produce measurable visceral fat reduction

This approach attempts to bypass digestion so the peptide can circulate throughout the body