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National Academies of Sciences E, Studies D on E and L, Research I for LA, Use R on S and W in LA (2018) Assessing Safety and Toxicology

This 6 kDa peptide hormone, naturally upregulated during childbirth to soften the cervix, has been studied for adhesive capsulitis (frozen shoulder) because it directly targets fibrosis, the underlying cause of the condition

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Biochemical analyses were performed on maternal serum, fetal brains, and adult prefrontal cortex, measuring IL-6 and IL-17a (ELISA), parvalbumin-positive interneurons (immunofluorescence), and GABA/glutamate levels (HPLC)