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Carrying this work into clinical application, the first human HTx procedure was performed in 1992 utilizing autologous hepatocytes for individuals with cirrhotic liver (Mito et al., 1992)

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Conditional depletion of HGF in CAFs resulted in decreased development of liver cancer, and depletion of the HGF receptor MET in hepatocytes or tumour compartments reduced tumour growth [230]

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