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In preclinical models that simulate stress-induced depression, supplementation with Ashwagandha has been shown to markedly reduce the release of cytokines, restore antioxidant defenses (e.g., glutathione, superoxide dismutase), and lower markers indicative of oxidative stress (82)

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10.1186/1750-1326-2-1 [DOI] [PMC free article] [PubMed] [Google Scholar] 113.Rey P, Lopez-Real A, Sanchez-Iglesias S, Munoz A, Soto-Otero R, Labandeira-Garcia JL