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Role of JNK isoforms in the kainic acid experimental model of epilepsy and neurodegeneration

Other inflammatory cells, such as activated phagocytes (including neutrophils, eosinophils, and mononuclear phagocytes), also produce ROS, further exacerbating oxidative stress in the TME and influencing the interactions among different cell types [51, 52]

These transporters function alongside a cytoplasmic Cu I netallochaperone that plays a role in buffering cytoplasmic Cu I to very low concentrations (Figure 8) and is capable of delivering Cu I directly to an exporter for efflux 875,876 and in some cases, to the Cu I -sensing transcriptional repressor that orchestrates the adaptive response Cu toxicity (Figure 34)