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Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis

NAC may be supportive in APD by: Helping replenish glutathione, which plays a role in regulating immune responses Reducing oxidative stress that can worsen mast cell activation and inflammation Supporting overall inflammatory balance, particularly during hormonally driven immune flares Some research also suggests NAC may influence mast cellmediated pathways indirectly 13 , which may be relevant in conditions where histamine release contributes to symptoms

65 Similarly, adding GSH to Pseudomonas cultures helped restore host-cell GSH recycling and prevented antibiotic-induced oxidative injury

Rosuvastatin is processed by the liver, and glutathione is the livers primary tool for cellular defence