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Significant upregulation of aISC ( Lgr5 , Slc12a2 and Ascl2 ) and rISC markers ( Hopx , Bmi1 and Lrig1 ) were observed along with increased makers of intestinal secretory linages, including Paneth cells ( Lyz1 , Ang4 and Agr2 ), Goblet cells ( Ccl9 and Muc2 ), and Tuft cells ( Dclk1 and Cd24a ) in the IPA-treated WT B6 mice versus Veh controls at D3 and D7 (Fig

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