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Enteroendocrine cells (EECs), the microbiota, and metabolites produced by the microbiota constitute a complex signaling system [13] that involves the enteric plexus, CNS afferents and efferents, and the modulation of numerous brain nuclei like the nucleus tractus solitarius, hypothalamus, thalamus, and many others directly involved in the control of glucose and energy homeostasis [14]

Clinical manifestations may involve multiple systems, including neurological, gastrointestinal, and musculoskeletal domains

You can take a test to check your gut

Hultman American Journal of Physiology-Endocrinology and Metabolism 1994 266:5, E725-E730 Baker JS, McCormick MC, Robergs RA