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The overexpression of miR-21-3p correlates with the inhibition of critical neuronal and synaptic genes such as DLGAP1 , which decreased the expression of Protocadherin-19 ( PCDH19 ), associated with cognitive impairment

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NOS inhibition also blunts both sensitization and behavioral despair that occurs during amphetamine withdrawal (Liu et al., 2011

Many patients who do not meet hypermobile EDS criteria and do not have clear evidence for another specific syndrome will meet criteria for hypermobility spectrum disorders