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Moreover, neurexins, key molecules involved in the regulation of synaptic plasticity, act as critical links between synaptic plasticity and sustained antidepressant effects, involving mechanisms including protein level, selective splicing, epigenetics, astrocytes, positional redistribution and protein structure

In freshwater lakes with flows in and out via rivers, the average residence time is 1 to 100 years, while in salt lakes, from which the only exit is likely to be by evaporation, the average residence time is up to 1000 years

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This could mean that the anticoagulant effect of SSRIsassuming that microclots played a role in these patientsmight contribute to their response