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The blunted inhibition of hexokinase by glucose-6-phosphate is important not only for allowing high rates of upstream glycolysis and ensuring avid glucose uptake from the extracellular space, but also because glucose-6-phosphate may originate from galactose (through glucose-1-phosphate), glycogen (through glycophagy and/or glycogenolysis), and ribose (through the pentose phosphate pathway forming fructose-6-phosphate), (Fig

An acute overdose depletes glutathione stores in the liver NAPQI accumulates causing hepatocellular necrosis and possibly damage to other organs