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Dick [Redox Regulation, DKFZ, Heidelberg]), which globally expresses an H 2 O 2 sensor (ROSA26/CAG-stop fl -mito-roGFP2-Orp1 CMV-Cre) targeted to the mitochondrial matrix, was crossbred with the Taz -KD and corresponding wild-type (WT) mice

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Most of the existing studies have focused on the regulation of core molecules of the AMPK pathway (such as ACC, mTOR, and SEBP-1C), but its interaction with other metabolic pathways (such as PI3K/Akt, FGF21, and the gut microbiota-liver axis) has not been fully clarified, which limits the comprehensive understanding of the complex regulatory network in NAFLD