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Neurology 2010
"Tobacco is one of the most relapse-prone substances because it rewires the neural circuits," he told Internatinoal Business Times on the occasion of No-Tobacco Day observed annually on May 31
Whereas most of the included studies were varied in quality from low to high, most studies had small sample size and only two had large sample size, participants were predominantly male, used different comparison groups, done at different settings, most of the studies were done in the USA, and some of the studies did not report the related findings of NRT effect
13 Furthermore, 80% of published efficacy RCTs of antidepressants for major depression from 1995 through 2014 excluded people with AUD or a SUD
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