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Maus M, Lpez-Polo V, Mateo L, Lafarga M, Aguilera M, De Lama E, et al

Studies have shown that glutamate exposure or hypoxia/ischemia can trigger the activation of extrasynaptic NMDARs, activate the shutdown of cAMP response element-binding protein (CREB), and lead to mitochondrial membrane-potential loss and cell death (Figure 1)

Interaction of nobiletin with methotrexate ameliorates 7-OH methotrexate-induced nephrotoxicity through endoplasmic reticulum stress-dependent PERK/CHOP signaling pathway

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