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Both JFK and FDR suffered from chronic sinus infections as a result of smoking Smoking has long been linked to various diseases, and it seems that few long-term smokers can avoid all of the associated health complications, such as chronic sinus problems

Since the mid-1980s, oncogenes have been identified in the tumor DNA of many human neoplasms as well as in spontaneous and chemically-induced neoplasms in animals (Table 5.8)

This decision was made based on the conclusion that mutations in ASXL1 and DNMT3A were age-acquired and related to smoking behaviors