If a patient is suspected to be experiencing OIH, carefully consider appropriately decreasing the dose of the current opioid analgesic, or opioid rotation (safely switching the patient to a different opioid moiety) (see DOSAGE AND ADMINISTRATION, WARNINGS)
While powerful, this approach becomes limiting in the search for general features that impact metal selectivity in a superfamily of proteins that do not necessarily share all specific features of the model protein
By using this tool, you can plan your doses, monitor effects, and manage peptides efficiently
Local inhibition is still fine, because you wont get the systemic/brain inhibition, leading to depression, anxiety, insomnia, overstimulation, sexual dysfunction, etc