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Retrieved 15 July 2024

22nd Century positioned its progress alongside regulatory developments, including a January 2025 proposed rule by the U.S

Fairclough G

Exposure to a foreign body causes a sterile inflammatory reaction in the intrauterine environment that is toxic to sperm and ova and impairs implantation.28,29 The production of cytotoxic peptides and activation of enzymes lead to inhibition of sperm motility, reduced sperm capacitation and survival, and increased phagocytosis of sperm.30,31