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Some factors that have been proposed include: promoting the release of pro-inflammatory cytokines, signaling proteins that promote inflammation scarring of your hair follicles due to increased levels of cytokines changing enzyme levels that control tissue remodeling in your hair growth cycle increasing hydroxylation of the hormone estradiol and inhibition of the enzyme aromatase that leads to a state of low estrogen levels Along with contributing to hair loss, smoking may negatively impact your hair health in a number of other ways