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It has been well established that the cerebellum is essential for adaptive motor learning, which optimizes the force and timing of individual muscle contractions for accurate movements, and recent studies also suggest a role for the cerebellum in higher-order adaptive control of actions [342]

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The binding energies were converted to predicted dissociation constants (Kd) using the relationship G = RT ln(Kd): HSP90AA1: Kd 40 M (G = 5.79 kcal/mol)