glutathione and alzheimer's Role of oxidative stress in neurodegeneration (GSH = glutathione; GSSG Elevation of glutathione as a

Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing

It is not clear how DHA affects brain function, but changes in DHA content of neuronal cell membranes could alter the function of ion channels or membrane-associated receptors, as well as the availability of neurotransmitters (94)

Crit Rev Biotechnol 16(4):349362 Niidome T, Huang L (2002) Gene therapy progress and prospects: nonviral vectors

Theo di sc khe nh k: Ngi dng cn theo di tnh trng sc khe trong qu trnh s dng L-glutathione