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3.1.2 Direct effects of inflammation on classical neurotransmitter systems Beyond Trp metabolism, inflammation directly affects the synthesis, release, and receptor function of classical neurotransmitters, thereby exacerbating neural circuit dysfunction associated with EDC

Thus, heterosynaptic changes in inhibitory neurons were weight-dependent: Inputs with initially high paired-pulse ratio (low release probability, weak inputs) tended to be potentiated while inputs with initially low paired-pulse ratio (high release probability, strong synapses) tended to depress or did not change after intracellular tetanization

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Sybiya Vasantha Packiavathy IA, Agilandeswari P, Musthafa KS, Pandian SK, Ravi AV (2012) Antibiofilm and quorum sensing inhibitory potential of Cuminum cyminum and its secondary metabolite methyl eugenol against Gram negative bacterial pathogens