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The impact of histone modifications on OA Histone modifications play a crucial role in the pathogenesis of OA by regulating gene expression and cellular functions

Dietary interventions, such as supplementation with specific flavonoids (e.g., ligustrazine II), can ameliorate metabolic disorders and alleviate depressive symptoms by reshaping the gut microbiota, increasing SCFAs production, and reducing systemic and neuroinflammatory responses (Luo et al., 2025)

Genotyping Genomic DNA was isolated from blood samples (Puregene Systems, Gentra)

This upregulation extends to key antioxidant systems, including glutathione (GSH) and thioredoxin (TRX), which help maintain redox balance and support tumor survival [35]