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(2024) reported that epileptic seizures can induce microglial activation and trigger a cascade involving the NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome, leading to elevated pro-inflammatory cytokine levels, aggravated neuronal damage, and depression-like behaviors
They include flavanols (catechins), flavonols (kaempferol, quercetin), flavones (apigenin, luteolin), flavanones (hesperidin, naringenin), and anthocyanins [179]
However, a 145-patient randomised controlled trial (RCT) reported that 4 g of paracetamol daily in divided doses for 4 days was associated with an increase in ALT activity in a significant proportion of patients when compared to placebo, although the clinical significance of this elevation in ALT is unclear [24]
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