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Kishimoto, et al

CAR domains were comprised of CD8 leader, anti-muFAP scFV, CD8 hinge, CD28 transmembrane (TMD) and 4-1BB & CD3 intracellular signal

In RA, synovial macrophages and T cells excessively secrete TNF-, driving synovial hyperplasia and inducing IL-6 and IL-1 release, which forms an inflammatory amplification loop and leads to cartilage and bone destruction (66)