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For hair, PDRN is most useful in patients whose hair loss has an inflammatory or post-inflammatory component: telogen effluvium after stress, hair loss following autoimmune flares, recovery after hair transplant procedures, or scalp inflammation accompanying conditions like seborrheic dermatitis

76 In contrast, silencing and down-regulation of cellular BNIP3 levels by siRNA inhibited mitophagy, which led to an increasing ROS level and a decreased protein level of the antioxidant MnSOD