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Painful feet caused by footpad lesions are common

Apart from ROS being created as a result of oxidative glucose metabolism, the constant exposure of retinal cells to sunlight and artificial light triggers the production of ROS 16,17 , especially with photosensitizers present, such as retinoids 16,18 , and leads to photo-oxidation 19

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While some individuals may notice a subtle shift in mental clarity or energy within the first few days, for most, the real work happens at a cellular level over weeks and months